2020 – 2021

Alonso-Padilla J, Abril M, Alarcón de Noya B, Almeida IC, Angheben A, Araujo Jorge T, Chatelain E, Esteva MI, Gascón J, Grijalva MJ, Guhl F,Hasslocher-Moreno AM, López MC, Luquetti A, Noya O, Pinazo MJ, Ramsey JM, Ribeiro I, Ruiz AM, Schijman AG, Sosa-Estani S, Thomas MC, Torrico F, Zrein M, Picado A. Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus. PLoS Negl Trop Dis. 2020 Apr 23;14(4):e0008035. doi: 10.1371/journal.pntd.0008035. eCollection 2020 Apr.

Álvarez MG, Ramírez JC, Bertocchi G, Fernández M, Hernández Y, Lococo B, Lopez-Albizu C, Schijman A, Cura C, Abril M, Laucella S , Tarleton RL, Natale MA, Castro Eiro M, Sosa-Estani S, Viotti R. New scheme of intermittent benznidazole administration in patients chronically infected with Trypanosoma cruzi: Clinical, parasitological and serological assessment after three years of follow-up. Antimicrob Agents Chemother. 2020 22 de junio: AAC.00439-20. doi: 10.1128 / AAC.00439-20. En línea antes de la impresión.PMID: 32571827

Bertelli A, Sanmarco LM, Pascuale CA, Postan M, Aoki MP, Leguizamón MS. Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection. Front Cell Infect Microbiol. 2020 Jul 2;10:285. doi: 10.3389/fcimb.2020.00285. eCollection 2020. PMID: 32714876

Milduberger Natalia, Bustos Patricia L., Gonzalez Carolina, Perrone Alina E., Postan Miriam, Bua Jacqueline. Trypanosoma cruzi infection in Cyclophilin D deficient mice. Exp Parasitol 2021 Jan; 220:108044. doi: 10.1016/j.exppara.2020.108044. Epub 2020 Nov 27

Parodi C, Barrio A, García Bustos MF, González Prieto AG, Pimentel J, Badano N, Albareda MC, Castro Eiro ME, Laucella SA, de Elizalde de Bracco MM. B cell profile, B-cell activating factor concentration and IgG levels in human cutaneous and mucosal leishmaniasis. Parasite Immunol. 2020 May 27:e12759. doi: 10.1111/pim.12759. Online ahead of print. PMID: 32460372

Quebrada Palacio LP, Fernández ER, Hernández-Vásquez Y, Petray PB, Postan M. Circulating T Follicular Helper Cell Abnormalities Associated to Different Clinical Forms of Chronic Chagas Disease. Front Cell Infect Microbiol. 2020 Mar 31;10:126. doi: 10.3389/fcimb.2020.00126. eCollection 2020.PMID: 32296649

Rial Marcela S , Seremeta Katia P , Esteva MI , Búa Jacqueline , Salomon Claudio J , Fichera Laura E . In vitro studies and preclinical evaluation of benznidazole microparticles in the acute Trypanosoma cruzi murine model Parasitology. 2020 Dec 10;1-38. doi: 10.1017/S0031182020002310. Online ahead of print. PMID: 33298212

Rial MS, Arrúa EC, Natale MA, Bua J, Esteva MI, Prado NG, Laucella SA, Salomon CJ, Fichera LE Efficacy of continuous versus intermittent administration of nanoformulated benznidazole during the chronic phase of Trypanosoma cruzi Nicaragua infection in mice. Journal of Antimicrobial Chemotherapy, dkaa101, https://doi.org/10.1093/jac/dkaa101. Published:10 April 2020.

Rodríguez Matías Exequiel, Rizzi Mariana,  Caeiro D., Yamil E. Masip, Alina Perrone, Daniel O. Sánchez, Jacqueline Búa, Valeria Tekiel “Transmigration of Trypanosoma cruzi trypomastigotes through 3D cultures resembling a physiological environment”  Cellular Microbiology. 2020;e13207. https://doi.org/10.1111/cmi.13207

Tasso LM, Bruballa AC, Garavaglia PA, Esteva MI, Albareda MC, García GA. Effect of the Tc13Tul antigen from Trypanosoma cruzi on splenocytes from naïve mice. Parasitology. 2020 May 29:1-39. doi: 10.1017/S0031182020000864. Online ahead of print. PMID: 32466805

Fernández ML, Marson ME, Mastrantonio GE, Corti MA, Fleitas U, Lloveras SC, Lista N, Priarone MM, Domínguez C, Garcia-Bournissen F. Benznidazole in cerebrospinal fluid. A case series of chagas disease meningoencephalitis in hiv positive patients. Antimicrob Agents Chemother. 2020 Dec 23:AAC.01922-20. doi: 10.1128/AAC.01922-20. Online ahead of print. PMID: 33361290

Lopez-Albizu C, Bravo MP, Pico M, Fernandez ML.Case report of Chagas disease reactivation: new diagnosis tool by direct microscopic observation of biopsy specimen and its preservation fluid. Rev Soc Bras Med Trop. 2020 Dec 21;54:e20200326. doi: 10.1590/0037-8682-0326-2020. eCollection 2020. PMID: 33338120

Besuschio SA, Picado A, Muñoz-Calderón A, Wehrendt DP, Fernández M, Benatar A, Diaz-Bello Z, Irurtia C, Cruz I, Ndung’u JM, Cafferata ML, Montenegro G, Sosa Estani S, Lucero RH, Alarcón de Noya B, Longhi SA, Schijman AG. Trypanosoma cruzi loop-mediated isothermal amplification (Trypanosoma cruzi Loopamp) kit for detection of congenital, acute and Chagas disease reactivation. PLoS Negl Trop Dis. 2020 Aug 14;14(8):e0008402. doi: 10.1371/journal.pntd.0008402. eCollection 2020 Aug. PMID: 32797041

Álvarez MG, Ramírez JC, Bertocchi G, Fernández M, Hernández Y, Lococo B, Lopez-Albizu C, Schijman A, Cura C, Abril M, Laucella S, Tarleton RL, Natale MA, Castro Eiro M, Sosa-Estani S, Viotti R. New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00439-20. doi: 10.1128/AAC.00439-20. Print 2020 Aug 20. PMID: 32571827

Molina-Morant D, Fernández ML, Bosch-Nicolau P, Sulleiro E, Bangher M, Salvador F, Sanchez-Montalva A, Ribeiro ALP, de Paula AMB, Eloi S, Correa-Oliveira R, Villar JC, Sosa-Estani S, Molina I. Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial. Trials. 2020 Apr 15;21(1):328. doi: 10.1186/s13063-020-4226-2. PMID: 32293523

Acevedo GR, Juiz NA, Ziblat A, Pérez Perri L, Girard MC, Ossowski MS, Fernández M, Hernández Y, Chadi R, Wittig M, Franke A, Nielsen M, Gómez KA. In Silico Guided Discovery of Novel Class I and II Trypanosoma cruzi Epitopes Recognized by T Cells from Chagas’ Disease Patients. J Immunol. 2020 Mar 15;204(6):1571-1581. doi: 10.4049/jimmunol.1900873. Epub 2020 Feb 14. PMID: 32060134

Cianciulli TF, Albarracín GA, Napoli Llobera M, Prado NG, Saccheri MC, Hernández Vásquez YM, Méndez RJ, Beck MA, Baez KG, Balletti LR. Speckle tracking echocardiography in the indeterminate form of Chagas disease. Echocardiography. 2020 Nov 3. doi: 10.1111/echo.14917. Online ahead of print. PMID: 33140890

Ciapponi A, Barreira F, Perelli L, Bardach A, Gascón J, Molina I, Morillo C, Prado N, Riarte A, Torrico F, Ribeiro I, Villar JC, Sosa-Estani S. Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2020 Aug 17;14(8):e0008529. doi: 10.1371/journal.pntd.0008529. eCollection 2020 Aug. PMID: 32804966

Cianciulli TF, Saccheri MC, Papantoniou A, Prado NG, Riarte AR, Méndez RJ, Clérici JE, Beck MA, Lax JA, Gagliardi JA. Clinical significance of tissue Doppler imaging in chronic Chagas disease. Echocardiography. 2020 Aug;37(8):1205-1212. doi: 10.1111/echo.14795. Epub 2020 Jul 20. PMID: 32686870

Cianciulli TF, Saccheri MC, Papantoniou A, Méndez RJ, Gagliardi JA, Prado NG, Riarte AR, Morita LA, Clérici JE, Lax JA. Use of tissue doppler imaging for the early detection of myocardial dysfunction in patients with the indeterminate form of Chagas disease. Rev Soc Bras Med Trop. 2020 Feb 21;53:e20190457. doi: 10.1590/0037-8682-0457-2019. eCollection 2020. PMID: 32130325

Macchiaverna NP, Enriquez GF, Bua J, Fernández MP, Sartor PA, Gürtler RE, Cardinal MV. Human infectiousness and parasite load in chronic patients seropositive for Trypanosoma cruzi in a rural area of the Argentine Chaco. Infect Genet Evol. Mar;78:104062. doi: 10.1016/j.meegid.2019.104062. Epub 2019 Nov 1. PMID: 31683004.

Crudo F, Piorno P, Krupitzki H, Guilera A, Lopez-Albizu C, Danesi E, Scollo K,Lloveras S, Mir S, Alvarez M , Yudis S, Cayo – Fernández MA, Cipri D, Krolewiecki A, Pereiro  AC, Periago MV, Abril  MC, Fernández M. How to implement the framework for the elimination of mother-to-child transmission of HIV, syphilis, hepatitis B and Chagas (EMTCT Plus) in a disperse rural population from the Gran Chaco region: A tailor-made program focused on pregnant women. PLOS Neglected Tropical Diseases, May 28, 2020. https://doi.org/10.1371/journal.pntd.0008078

Lopez-Albizu C,  Danesi E , Piorno P, Fernández M, García-Campos F, Scollo K, Favio Crudo F. Rapid Diagnostic Tests for Trypanosoma cruzi Infection: Field Evaluation of Two Registered Kits in a Region of Endemicity and a Region of Nonendemicity in Argentina. Journal of Clinical Microbiology. December 2020 Volume 58 Issue 12 e01140-20.

Alonso-Padilla J, López MC, Esteva M, Zrein M, Casellas A, Gómez I, Granjon E, Méndez S, Benítez C, Ruiz AM, Sanz S, Gascón J, Thomas MC, Pinazo MJ; NHEPACHA Study Group. Serological reactivity against T. cruzi-derived antigens: Evaluation of their suitability for the assessment of response to treatment in chronic Chagas disease. Acta Trop. 2021 Sep;221:105990. doi: 10.1016/j.actatropica.2021.105990. Epub 2021 Jun 6.PMID: 34090864

Benatar AF, Danesi E, Besuschio SA, Bortolotti S, Cafferata ML, Ramirez JC, Albizu CL, Scollo K, Baleani M, Lara L, Agolti G, Seu S, Adamo E, Lucero RH, Irazu L, Rodriguez M, Poeylaut-Palena A, Longhi SA, Esteva M, Althabe F, Rojkin F, Bua J, Sosa-Estani S, Schijman AG; Congenital Chagas Disease Study Group. Prospective multicenter evaluation of real time PCR Kit prototype for early diagnosis of congenital Chagas disease. 2021 Jul;69:103450. doi: 10.1016/j.ebiom.2021.103450. Epub 2021 Jun 26.PMID: 34186488

Bisio MMC, Rivero R, Gonzalez N, Ballering G, D’Amico I, Kessler C, Moroni S, Moscatelli G, Ruiz AM, Altcheh J. Diagnostic Accuracy of Two Molecular Tools for Diagnosis of Congenital Chagas Disease. Mol Diagn Ther. 2021 Nov;25(6):791-801. doi: 10.1007/s40291-021-00553-3. Epub 2021 Aug 23.PMID: 34426953

Castro Eiro MD, Natale MA, Alvarez MG, Shen H, Viotti R, Lococo B, Bua J, Nuñez M, Bertocchi GL, Albareda MC, Cesar G, Tarleton RL, Laucella SA. Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.J Antimicrob Chemother. 2021 May 12;76(6):1580-1592. doi: 10.1093/jac/dkab054.PMID: 33693664

Milduberger N, Bustos PL, González C, Perrone AE, Postan M, Bua J. Trypanosoma cruzi infection in Cyclophilin D deficient mice. Exp Parasitol. 2021 Jan;220:108044. doi: 10.1016/j.exppara.2020.108044. Epub 2020 Nov 27.PMID: 33253715

Natale MA, Minning T, Albareda MC, Castro Eiro MD, Álvarez MG, Lococo B, Cesar G, Bertocchi G, Elias MJ, Caputo MB, Tarleton RL, Laucella SA. Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro. PLoS Negl Trop Dis. 2021 Jun 1;15(6):e0009473. doi: 10.1371/journal.pntd.0009473. eCollection 2021 Jun.PMID: 34061845

Rial MS, Seremeta KP, Esteva MI, Búa J, Salomon CJ, Fichera LE. In vitrostudies and preclinical evaluation of benznidazole microparticles in the acute Trypanosoma cruzi murine model. 2021 Apr;148(5):566-575. doi: 10.1017/S0031182020002310. Epub 2020 Dec 10.PMID: 33298212

Soprano LL, Ferrero MR, Landoni M, García GA, Esteva MI, Couto AS, Duschak VG. Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and Favor Trypanosoma cruziInfection in the BALB/c Mice Model of Experimental Chagas Disease. Front Cell Infect Microbiol. 2022 Jan 4;11:814276. doi: 10.3389/fcimb.2021.814276. eCollection 2021.PMID: 35059328

Valera-Vera EA, Concepción JL, Cáceres AJ, Acevedo GR, Fernández M, Hernández Y, Digirolamo FA, Duschak VG, Soprano LL, Pereira CA, Miranda MR, Gómez KA. IgE antibodies against Trypanosoma cruzi arginine kinase in patients with chronic Chagas disease. Mol Immunol. 2021 Oct;138:68-75. doi: 10.1016/j.molimm.2021.06.024. Epub 2021 Aug 4.PMID: 34364074

Viecenz JM, Garavaglia PA, Tasso LM, Maidana CG, Bautista Cannata JJ, García GA. Identification and biochemical characterization of an ATP-dependent dihydroxyacetone kinase from Trypanosoma cruzi. Exp Parasitol. 2021 Dec;231:108178. doi: 10.1016/j.exppara.2021.108178. Epub 2021 Nov 10.PMID: 34767777

Volta BJ, Bustos PL, González C, Natale MA, Perrone AE, Milduberger N, Laucella SA, Bua J. Circulating Cytokine and Chemokine Profiles of Trypanosoma cruzi-Infected Women During Pregnancy and Its Association With Congenital Transmission. J Infect Dis. 2021 Sep 17;224(6):1086-1095. doi: 10.1093/infdis/jiab057.PMID: 33528501

Duschak VG, Relevance of Sulfotopes in the Antigenic Structural Glycoconjugates of Trypanosoma cruzi, the Causal Agent of Chagas Disease, Identified by UV MALDI-TOFAnalysis. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 101:224-225. DOI:10.1016/j.ijid.2020.11.023

Miriam Postan and Martin E. Rottenberg. Editorial: Neurotropism of Parasites and the Immune Responses Editorial Published on 01 October 2021 Front. Immunol. doi: 10.3389/fimmu.2021.775666