2016 – 2017 – INP – Dr. Mario Fatala Chaben

Alvarez MG, Bertocchi GL, Cooley G, Albareda MC, Viotti R, Perez-Mazliah DE, Lococo B, Castro Eiro M, Laucella SA, Tarleton RL.Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses. PLoS Negl Trop Dis. 2016 Apr 29;10(4):e0004657. doi: 10.1371/journal.pntd.0004657. PMID: 27128444
Ayala MA, Casasco A, González M, Postan M, Corral RS, Petray PB. Trypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6. Parasitol Res. 2016 Feb;115(2):779-85. doi: 10.1007/s00436-015-4805-4. PMID: 26526953
Duschak VG. Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period. Recent Pat Antiinfect Drug Discov. 2016 Oct 24. PMID: 27784230
Enriquez GF, Garbossa G, Macchiaverna NP, Argibay HD, Bua J, Gürtler RE, Cardinal MV. Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism? Vet Parasitol. 2016 Jun 15;223:186-94. doi: 10.1016/j.vetpar.2016.04.042. PMID: 27198799
Ferrero MR, Heins AM, Soprano LL, Acosta DM, Esteva MI, Jacobs T, Duschak VG. Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E. Med Microbiol Immunol. 2016 Feb;205(1):21-35. doi: 10.1007/s00430-015-0421-2. PMID: 26047932
Garavaglia PA, Laverrière M, Cannata JJ, García GA. Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2664-70. doi: 10.1128/AAC.02185-15. PMID: 26856844
Juiz NA, Cayo NM, Burgos M, Salvo ME, Nasser JR, Búa J, Longhi SA, Schijman AG. Human Polymorphisms in Placentally Expressed Genes and Their Association With Susceptibility to Congenital Trypanosoma cruzi Infection. J Infect Dis. 2016 Apr 15;213(8):1299-306. doi: 10.1093/infdis/jiv561. PMID: 26597259
Lauricella MA, Maidana CG, Frias VF, Romagosa CM, Negri V, Benedetti R, Sinagra AJ, Luna C, Tartaglino L, Laucella S, Reed SG, Riarte AR. An rK28-Based Immunoenzymatic Assay for the Diagnosis of Canine Visceral Leishmaniasis in Latin America.Am J Trop Med Hyg. 2016 Jul 6;95(1):92-8. doi: 10.4269/ajtmh.13-0768. PMID: 27162270
Scalise ML, Arrúa EC, Rial MS, Esteva MI, Salomon CJ, Fichera LE. Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies. Am J Trop Med Hyg. 2016 Aug 3;95(2):388-93. doi: 10.4269/ajtmh.15-0889. PMID: 27246447
Volta BJ, Bustos PL, Cardoni RL, De Rissio AM, Laucella SA, Bua J. Serum Cytokines as Biomarkers of Early Trypanosoma cruzi infection by Congenital Exposure. J Immunol. 2016 Jun 1;196(11):4596-602. doi: 10.4049/jimmunol.1502504. PMID: 27183607
Sartor P, Colaianni I, Cardinal MV, Bua J, Freilij H, Gürtler RE. Improving access to Chagas disease diagnosis and etiologic treatment in remote rural communities of the Argentine Chaco through strengthened primary health care and broad social participation. PLoS Negl Trop Dis. 2017 Feb 13;11(2):e0005336. doi: 10.1371/journal.pntd.0005336. PMID: 28192425
Bustos PL, Volta BJ, Perrone AE, Milduberger N, Bua J. A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress-damage response. Cell Death Discov. 2017 Feb 6;3:16092. doi: 10.1038/cddiscovery.2016.92. PMID: 28179991
Rivero R, Bisio M, Velázquez EB, Esteva MI, Scollo K, González NL, Altcheh J, Ruiz AM. Rapid detection of Trypanosoma cruzi by colorimetric loop-mediated isothermal amplification (LAMP): A potential novel tool for the detection of congenital Chagas infection. Diagn Microbiol Infect Dis. 2017 Sep;89(1):26-28. doi: 10.1016/j.diagmicrobio.2017.06.012. Epub 2017 Jun 19. PMID:28684052
Rojas F, Koszela J, Búa J, Llorente B, Burchmore R, Auer M, Mottram JC, Téllez-Iñón MT. The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei. PLoS Negl Trop Dis. 2017 Jun 13;11(6):e0005626. doi: 10.1371/journal.pntd.0005626. [Epub ahead of print] PMID: 28609481
Vilma G Duschak. Advances in the Neglected Chagas Disease: Drug Targets and Trypanocide Compounds. Curr Trends Biomedical Eng & Biosci. 2017; 6(4): 555693. DOI: 10.19080/CTBEB.2017.06.555693.
Hong XK, Zhang X, Fusco OA, Lan YG, Lun ZR, Lai DH. PCR-based identification of Trypanosoma lewisi and Trypanosoma musculi using maxicircle kinetoplast DNA. Acta Trop. 2017 Jul;171:207-212. doi: 10.1016/j.actatropica.2017.04.007. Epub 2017 Apr 17.
González L1, García-Huertas P, Triana-Chávez O, García GA, Murta SMF, Mejía-Jaramillo AM. Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi. Mol Microbiol. 2017 Sep 7. doi: 10.1111/mmi.13830. [Epub ahead of print]
Bustos PL, Perrone AE, Milduberger NA, Bua J. Mitochondrial permeability transition in protozoan parasites: what we learned from Trypanosoma cruzi. Cell Death Dis. 2017 Sep 21;8(9):e3057. doi: 10.1038/cddis.2017.431. PMID: 28933785
Castro Eiro MD, Alvarez MG, Cooley G, Viotti RJ, Bertocchi GL, Lococo B, Albareda MC, De Rissio AM, Natale MA, Parodi C, Tarleton RL, Laucella SA. The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to Trypanosoma cruzi in Serodiscordant Subjects. Front Immunol. 2017 Sep 15;8:1141. doi: 10.3389/fimmu.2017.01141. eCollection 2017. PMID:28966620
Pascuale CA, Burgos JM, Postan M, Lantos AB, Bertelli A, Campetella O, Leguizamón MS. Inactive trans-Sialidase Expression in iTS-null Trypanosoma cruzi Generates Virulent Trypomastigotes. Front Cell Infect Microbiol. 2017 Oct 4;7:430. doi: 10.3389/fcimb.2017.00430. eCollection 2017. PMID: 29046868
Rial MS, Scalise ML, Arrúa EC, Esteva MI, Salomon CJ, Fichera LE. Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease. PLoS Negl Trop Dis. 2017 Dec 21;11(12):e0006119. doi: 10.1371/journal.pntd.0006119. [Epub ahead of print]. PMID: 29267280
Soprano LL, Parente JE, Landoni M, Couto AS, Duschak VG.Trypanosoma cruzi serinecarboxipeptidase is a sulfated glycoprotein and a minor antigen in human Chagas disease infection. Med Microbiol Immunol. 2017 Dec 22. doi: 10.1007/s00430-017-0529-7. [Epub ahead of print]. PMID: 2927401
Carolina I. Cura, Juan C. Ramírez, Marcelo Rodríguez, Constanza Lopez Albízu, Lucía Irazu, Karenina Scollo, Sergio Sosa-Estani.Comparative Study and Analytical Verification of PCR Methods for the Diagnosis of Congenital Chagas Disease. The Journal of Molecular Diagnostics. September 2017.Vol 19 (5): 673-681.
Lucas Gonzalez#, Karenina Scollo#, Ariel Bardach, Amadeo Sáez-Alquezar, Carina Ferlín, Pedro Albajar-Viñas, Agustín Ciapponi, Sergio Sosa-Estani.
Inmunoserología y métodos moleculares para el diagnóstico de Chagas: revisión sistemática rápida. Acta Bioquím Clín Latinoam 2017; 51 (1): 63-74
Carlos A. Morillo, Hetty Waskin, Sergio Sosa-Estani, Maria del Carmen Bangher, Carlos Cuneo, Rodolfo Milesi, Marcelo Mallagray, Werner Apt, Juan Beloscar, Joaquim Gascon, Israel Molina, Luis E. Echeverria, Hugo Colombo, Jose Antonio Perez-Molina, Fernando Wyss, Brandi Meeks, Laura R. Bonilla, Peggy Gao, Bo Wei, Michael McCarthy, Salim Yusuf, STOP-CHAGAS Investigators, Carlos Morillo, Sergio Sosa-Estani, Hetty Waskin, Brandi Meeks, Salim Yusuf, Rafael Diaz, Harry Acquatella, Julio Lazzari, Robin Roberts, Mahmoud Traina, Brandi Meeks, Laura R. Bonilla, Peggy Gao, Amanda Taylor, Iris Holadyk-Gris, Lindsey Whalen, M.C. Bangher, M.A. Romero, N. Prado, Y. Hernández, M. Fernandez, A. Riarte, K. Scollo, C. Lopez-Albizu, C.A. Cuneo, N.C. Gutiérrez, R.R. Milesi, M.A. Berli, M.H. Mallagray, N.E. Cáceres, J.S. Beloscar, J.M. Petrucci, H. Colombo, M. Dellatorre, Aldo Prado, W. Apt, I. Zulantay, L.E. Echeverría, D. Isaza, E. Reyes, F.S. Wyss, A. Figueroa, I. Guzmán Melgar, E. Rodríguez, J. Gascon, E. Aldasoro, E.J. Posada, N. Serret, I. Molina, A. Sánchez-Montalvá, J.A. Perez-Molina, R. López-Vélez, P.A. Reyes-López. Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers. Journal of the American College of Cardiology 69 (8) 939-947; DOI:10.1016/j.jacc.2016.12.023. Febrero 2017.
Rial Marcela Silvina , Scalise María Luján , López Alarcón Micaela , Esteva Mónica Inés , Búa Jacqueline, Benatar Alejandro , Prado Nilda Graciela , Riarte Adelina Rosa , Fichera Laura Edith. Experimental combination therapy with low doses of Benznidazole and Allopurinol on chronic T. cruzi infection. En etapa de publicación : Revista Parasitology. 2017
Marisa Liliana Fernández – MD, Yolanda Hernández– MD, Professional assitances, Karenina Scollo – MSc Department Chief, Mónica Ines Esteva – MSc, Department Chief Adelina Rosa Riarte– MD, Expert consultor., Nilda Graciela Prado– MSc, Department Chief. Chagas cardiomyopathy associated with serological cure after trypanocidal treatment during childhood. En etapa de publicación Journal of the Brazilian Society of Tropical Medicine – RSBMT-2017-0364. 2017